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The application of NSAIDs in osteoarthritis treatment

Time:2014-12-23 (Tuesday) at 9:00-10:30 am

Location:The Report Meeting Room, The biotech building

Lecturer: Dr. & Prof. Jian-sheng Wang

Lund University Hospital, Sweden

Abstract:

      Currently there is no absolute cure for osteoarthritis (OA). The ultimate goal of medical treatment of OA is to reduce the joint pain and stiffness and help patients maintain mobility. There are many medicines are available to help patients with OA. These medicines could be taken by oral, by injection, or directly apply on the skin. There are several classes of drugs are used in OA treatment including: analgesics, nonsteroidal anti-inflammatory drugs (NSAIDs), local pain relievers, corticosteroid injections and hyaluronic acid injections.

      NSAIDs are the most commonly used drugs to ease arthritis-related pain, swelling and stiffness. It interfere the synthesis of hormone-like chemicals called prostaglandins. Prostaglandins are the most important contributors of inflammation in the body.

      Prostaglandins are synthesized by arachidonic acid which catalyzed by cyclooxygenase (COX) enzyme. There are two classes of COX enzymes, COX-1 and COX-2. Both enzymes produce prostaglandins that promote inflammation, pain, and fever. Nonsteroidal anti-inflammatory drugs (NSAIDs) block the COX enzymes and reduce prostaglandins throughout the body. As a consequence, the inflammation, pain, and fever are reduced. Since the prostaglandins could also promote platelet aggregation and protect gastric mucosa, the major side effects of NSAIDs are causing ulcers and bleeding.

      NSAIDs include aspirin, ibuprofen, naproxen and celecoxib (Celebrex). They aren’t for everyone. These drugs have been linked to an increase in gastrointestinal bleeding, stomach ulcers, heart attack and stroke. Patients with stomach ulcers, high blood pressure, asthma or kidney or liver disease, or take a blood-thinner medicine are not suggest to use NSAIDs to treat OA.

Resume of Lecturer:

      DR. Jian-Sheng Wang graduated fromZunyi Medical College in 1982. From 1983 to 1987, he had worked as resident surgeon in dept. of Surgery, Zunyi Medical College. From 1987 to 1990, he had been working as chief surgeonin dept. of orthopaedicsin Dalian Medical University Affiliated 2nd hospital; and as a visiting surgeon in Jishui-tan hospital in Beijing. In Dec 1990 he went to Sweden and started working as visiting doctor at dept of orthopaedicsin Lund University Hospital. In 1996, he had completed his PhD with the title of “bFGF for stimulation of bone formation in osteoinductive or conductive implants”, which had been published in Acta Orthopaedica Scandinavia. Since then, he has been working as senior researcher and as a head of Biomaterials and Biomechanics Labin Dept of Orthopedic. In 2010, he has been promoted to the Associate Professor. In 2012, he obtained Swedish Medical License (Board Certificate for Specialist) and is currently working at the clinic practice in Lund University Hospital.

      Jiansheng′s major research has been focusing on bone cementing technique, injectable bone substitutein the application of joint replacement and bone defect treatment. These researches lead to 60 peer-reviewed papers that have been published in the international journals and in Books as book chapter. He had jointed an EU project on new Biomaterials in joint replacement as principle investigator; and served as the expert reviewer for a number of International journals; and been invited to hold expert speech in more than 30 international conferences or workshop worldwide. Jiansheng has also served as a chairman in several international conference and symposium.

      In the past years, Jiansheng has been working as supervisor for a number of master students and PhD students. He has been served as a senior consultant for American Biomet Orthopaedic Company and Sweden Bone Support Company.

Contact:1806 group Guang-Bo Ge (Dr. & Asso. Prof.) (Tel: 84379317-601)

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